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The incidence of congenital hypothyroidism and its determinants from 2012 to 2014 in Shadegan, Iran: a case-control study
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Ehsan Keshavarzian, Ali Asghar Valipoor, Mohammad Reza Maracy
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Epidemiol Health. 2016;38:e2016021. Published online May 26, 2016
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DOI: https://doi.org/10.4178/epih.e2016021
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Abstract
OBJECTIVES
Congenital hypothyroidism (CH) is one of the major causes of preventable mental retardation in infants. The aim of this study was to determine the incidence of CH in Shadegan, Khuzestan Province, Iran from 2012 to 2014 and to identify the risk factors associated with CH.
METHODS A total of 203 cases were confirmed from 2012 to 2014 in Shadegan, with 66, 86, and 51 patients reported in 2012, 2013, and 2014, respectively. A total of 3,900, 3,991, and 4,050 live births occurred in 2012, 2013, and 2014, respectively. The controls (n=657) were selected using a random number table, and a case-control study was carried out to determine the risk factors for neonatal CH, including demographic, environmental, and medical factors.
RESULTS The incidence of CH was 17.0 per 1,000 live births in 2012, 21.5 per 1,000 live births in 2013, and 12.6 per 1,000 live births in 2014. This study showed that the likelihood of CH in children born to parents with a history of consanguineous marriage was 2.41 times greater than in children born to parents with no such history (odds ratio, 2.41; 95% confidence interval [CI], 1.65 to 3.53). This study also found that CH was 3.4 times more likely (95% CI, 2.29 to 5.20) in infants born in urban settings than in infants born in rural areas.
CONCLUSIONS The incidence of CH in Shadegan from 2012 to 2014 was approximately 17 times greater than the expected incidence in Iran. CH was associated with a history of consanguineous marriage and urbanization.
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Citations
Citations to this article as recorded by  - Risk factors for transient and permanent congenital hypothyroidism: a population-based case-control study
Fariba Abbasi, Leila Janani, Malihe Talebi, Hosein Azizi, Lotfali Hagiri, Shahnaz Rimaz
Thyroid Research.2021;[Epub] CrossRef - Pediatric Quality of Life in Congenital Hypothyroidism: an Indonesian Study
Nur Rochmah, Muhammad Faizi, Carrina Dewanti, Ahmad Suryawan
International Journal of Thyroidology.2020; 13(2): 150. CrossRef - Doğumsal Hipotiroidi ile Ebeveyn Yaşı İlişkisi
Hale TUHAN
Turkish Journal of Pediatric Disease.2019; : 1. CrossRef - The role of season and climate in the incidence of congenital hypothyroidism in Kerman province, Southeastern Iran
Narges Khanjani, Ahmad Ahmadzadeh, Bahram Bakhtiari, Farzan Madadizadeh
Journal of Pediatric Endocrinology and Metabolism.2017; 30(2): 149. CrossRef
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